The home side had a great chance to take the lead early on as Dean Marney played a crossfield ball to Geovanni, who neatly slipped the ball through to Craig Fagan in front of goal, but the Tigers winger could only drag his shot wide from the edge of the box.
Wigan took the lead via an own goal on five minutes as Kevin Kilbane swung in a low corner from the right which Hull defender Ricketts attempted to clear, but instead flicked the ball over the shoulder of Boaz Myhill and into the back of his own net.
The visitors then doubled their lead on 13 minutes as Valencia picked up the ball just inside his own half and ran with ease past the Tigers defence to slot the ball neatly through the legs of Myhill from ten yards.
Ian Ashbee had a chance to reply for Hull just before the break but he miscued his first-time shot from 12 yards.
The home side created a great chance minutes into the second half as Geovanni laid the ball off to Richard Garcia in space, but the Australian international saw his shot from just inside the area well turned over the bar by Chris Kirkland.
Wigan went further into the lead on 63 minutes as Valencia collected the ball on the right byline and played in a low cross towards Zaki, who sent the ball into the bottom corner of the net with a neat right-footed effort.
Five minutes later it was 4-0 to the visitors as Kirkland lofted the ball upfield onto the head of Hull defender Wayne Brown, who could only flick the ball back into the path of Heskey. He confidently rounded Myhill and slotted it home.
It was then 5-0 to Steve Bruce's men as Michael Brown played the ball back to Zaki, whose blistering shot from 12 yards was ruled to be over the line by the assistant referee as it crashed against the underside of crossbar and out.