"Matt's a left-sided centre-half and that gives us a bit of balance which we're very happy about.
"There's every chance he could be involved against Plymouth because he played in this division for most of last season and knows what it's all about."
City are expected to play a wing-back formation, with Wicks debuting alongside Ian Goodison and Justin Whittle in defence, and Andy Holt and Ben Petty pushing further up the flanks. David Beresford and Ryan Williams will drop to the bench, while there's a choice from Sneekes, Whitmore, Johnsson and Greaves for the three central midfield spots.
Mike Edwards is out as he serves the last of a three-match ban. Jason Van Blerk isn't expected to start as he is still lacking in fitness.
Brian Little said of the Aussie: "Jason should be in the 16 and if he isn't it's because Andy Holt played very well against Huddersfield.
"That's half the reason why we brought him here. Andy knows that there's an experienced guy waiting in the wings and it's up to him to perform well enough to keep his place.
"Jason has been with us for a week now and knows the lads a lot better and also how we play as a team - that's important from our point of view."
Paul Musselwhite will be in goal for the third consecutive game as Matt Glennon still isn't over a thigh injury.
Meanwhile, midfielder Scott Kerr has had surgery on a troublesome back injury, which has kept him out since he signed in the summer.
Expected line-up (5-3-2): Musselwhite; Petty, Whittle, Goodison, Wicks, Holt; Sneekes, Johnsson, Whitmore; Alexander, Rowe.
Subs from: Glennon, Van Blerk, Mohan, Greaves, Matthews, Williams, Beresford, Dudfield.