Hobbs, 22, joined the Tigers from Leicester until the end of the season on Tuesday to team back up with former Foxes boss Nigel Pearson.
Hull will be without Paul McShane, who has joined Barnsley in a two-month loan deal.
Pearson will also be able to call on James Harper after the midfielder missed the last two games due to a foot problem.
Goalkeeper Vito Mannone, on loan from Arsenal, is still working his way back to full fitness after a groin injury and winger Richard Garcia is making steady progress following knee surgery.
Pearson has no new injury or suspension problems as his side look to extend their unbeaten league run to eight games.