One man likely to miss out is Matt Glennon. Paul Musselwhite has kept him out for the last three games as the summer signing is currently struggling with injury. Glennon will be disappointed not to play after picking up the Carlisle United Player of the Year award last season.
Jason Van Blerk, Rodney Rowe and Lee Philpott aren't 100% fit at the moment and are unlikely to start.
Meanwhile Brian Little is hoping for supporters to get behind the team and help them get the crucial three points they need to get back on winning ways.
"What we also need at the moment is for everybody to stick with the team and get behind the cause."
Little also confirmed that City will go back to playing 4-4-2, with Mike Edwards expected to return after completing a three-match ban.
Expected line-up (4-4-2): Musselwhite; Petty, Whittle, Wicks, Edwards; Williams, Sneekes, Whitmore, Beresford; Alexander, Dudfield.
Subs from: Glennon, Mohan, Goodison, Van Blerk, Holt, Greaves, Johnsson, Matthews, Bradshaw, Rowe.