Liam Rosenior and Robert Koren picked up medial ligament and hamstring injuries respectively during Saturday's 4-2 defeat to Middlesbrough and will miss out.
Meanwhile, goalkeeper Vito Mannone has suffered a recurrence of a shoulder problem and will also be on the treatment table.
"We've got a few problems going into Monday," said Pearson.
"Liam Rosenior has picked up a medial ligament injury and it could be the end of his season, while Robert Koren's got a hamstring problem and with Vito Mannone it's his shoulder again."
Player-coach Nick Barmby, who has been sidelined for the last five matches due to a calf strain, remains sidelines.
Source: PA
Source: PA