Edwards will miss the next two games after the FA decided to extend his suspension for his dismissal at Scunthorpe three months ago. Ben Petty is expected to be recalled to the side at right-back. He lost his place due to injury but has played in recent Reserve games.
Wicks damaged his hamstring on Saturday. Andy Holt is expected to take up the left-back spot.
Jason Van Blerk is still missing despite completing a two-match suspension. He picked up an injury in last week's Reserve game after clashing with goalkeeper Matt Glennon.
Return to Hull City Online on Friday for full team news, expected line-up and Ref Watch.