He has since returned to the KC Stadium but is not expected to be fit until early to mid-February.
Mannone's loan replacement Brad Guzan is unlikely to play against Wigan as Aston Villa do not want him cup-tied.
Mannone, who has won seven caps for Italy's under-21 side, signed a new contract with the Gunners earlier this year but has been unable to establish himself as a regular in the side ahead of Manuel Almunia and Lukasz Fabianski.
Source: BBC Sport
Source: BBC Sport